About Editor-in-Chief(s)

   Zhang Haoling, Song Zhijing, Zhang Zhongwen, Doblin Sandai, Wang Wei｜张浩令宋志靖 张忠文 Sandai Doblin 王薇

About Associate editor(s)

   Zhang Haolong, Zhao Rui｜张浩龙 赵瑞

Book Description

   Unraveling the Intricate Interplay: Exploring ATP Homeostasis and ATP-Induced Cell Death in Disease Pathogenesis｜解开复杂的相互关系：探索疾病发病机制中ATP稳态和ATP诱导的细胞死亡

   In the intricate realm of biological research, it is crucial to comprehend the intricate interplay between ATP balance and the mechanism of ATP-induced cell death in order to unravel the pathogenesis of diverse diseases. This comprehensive review encompasses a wide spectrum, incorporating systemic and cellular frameworks, disease manifestations, and evolutionary processes. ATP regulation serves as a fundamental cornerstone of cellular function, acting as a vital regulator that governs the intricate activities within cells. Disruptions in the delicate balance of ATP can act as triggers for cell death, a phenomenon intricately intertwined with numerous disease conditions. Our discourse extends to embrace diseases such as neoplastic, neurological, and cardiovascular ailments, among others. Simultaneously, we conducted an extensive analysis of both internal and external dynamics that influence extracellular ATP levels, providing valuable insights into disease associations. By shedding light on the impact of ATP in the expansive realm of disease occurrence and evolutionary biology, our aim is to unravel the perpetual debates and mysteries surrounding ATP-induced cell death. Furthermore, we delve into the intricate connections between ATP and ATP-induced cell death from an evolutionary perspective. Ultimately, this review provides a glimpse into the future of research in this dynamic and rapidly advancing field, setting the stage for forthcoming waves of exploration and groundbreaking discoveries in the realm of biomedical research.