Overseas Chinese Press Inc is an comprehensive of bilingual publisher in New York, Includes the following imprints: Overseas Chinese Press, World Books Publishing, China Culture Press, World Science Publishing House, Empyrean Literature Publishing, etc. We are mainly publishes Literature, Arts, Biography, Lifestyle, Psychology and inspiration, Language, Academic research Works, publishes more than 500 Books a year. The language of publication is in English, Chinese and bilingual. ISBN allocation is relatively flexible, It can be submitted and approved at the same time. About 2-3 days give it to you. You need to Provide 5 copies of sample books within 60 days, and Cover file. Convenient us to register the book number, and in our website and Bookwire database query. Due to the needs of business development, we are now looking for regional agents for external cooperation.
AntimiR34a Nanoparticles Target Myocardial Repair after Myocardial Infarction in Mice2023-07-06 17:58Source:Horizon Academic
AntimiR34a Nanoparticles Target Myocardial Repair after Myocardial Infarction in Mice AntimiR34a 纳米颗粒靶向小鼠心肌梗死后心肌修复 Liu Longmei, Wang Zhongchao, Chai Zhaoqin, Yang Yanyan, Han Xuebin 刘龙梅 王仲朝 柴照琴 杨艳艳 韩学斌 Abstract: Objective To explore the application of RNA nanotechnology in targeted therapy for myocardial infarction. The antimiR34a nanoparticles were selected to observe their myocardial targeting effect and their role in myocardial repair. Methods C57BL/6J mice were randomly divided into three groups: sham group, myocardial infarction group, and myocardial infarction+antimiR34a nanoparticles group. The infarction was assessed by immunohistochemistry and echocardiography, the distribution of antimiR34a nanoparticles in mice was observed by small animal live imaging system, and post-infarction myocardial repair was assessed by measuring infarct area, testing ejection fraction, detecting TNF-α and caspase 3 levels. Results AntimiR34a nanoparticles were mainly distributed in the myocardial tissue of mice; compared with the sham group, the myocardium at the ligation site of mice in the infarct group became thinner, with reduced local motion and significantly reduced ejection fraction (P<0.05), and the levels of TNF-α and caspase 3 were significantly increased (P<0.05); compared with the myocardial infarct group, the myocardial infarction + antimiR34a nanoparticles group showed a significant increase in ejection fraction (P<0.05) and a significant decrease in TNF-α and caspase 3 levels (P<0.05), but they were still high compared with the sham group. Conclusion AntimiR34a nanoparticles target the myocardium and improve cardiac function, lowering TNF-α and caspase 3 levels, and exerting myocardial repair effects in mice with myocardial infarction. 摘要：目的：探讨 RNA 纳米技术在心肌梗死靶向治疗中的应用。选取 antimiR34a 纳米颗粒，观察其心肌靶向效应及在心肌修复中的作用。方法：将 C57BL/6J 小鼠随机分为三组：假手术组、心肌梗死组、心肌梗死 +antimiR34a 纳米颗粒组。通过病理学检查、超声心动图评估心梗情况，通过小动物活体成像观察 antimiR34a 纳米颗粒在小鼠体内的分布情况，通过测量梗死面积、检测射血分数、TNF-α 和 caspase3 水平评估心梗后心肌修复情况。结果：antimiR34a 纳米颗粒主要分布在小鼠心肌组织；与假手术组相比，心梗组小鼠结扎部位心肌变薄，局部运动减弱，射血分数明显减低（P<0.05），TNF-α 和 caspase 3 水平明显升高（P<0.05）；与心肌梗死组相比，心肌梗死+antimiR34a纳米颗粒组的射血分数明显提升（P<0.05），TNF-α 和 caspase 3 水平显著降低（P<0.05），但跟假手术组相比仍然偏高。结论：AntimiR34a 纳米颗粒可以靶向心肌并改善心功能，调低 TNF-α 和 caspase 3 水平，发挥对心肌梗死小鼠的心肌修复作用。 Key words: nanoparticles; myocardial infarction; myocardial repair in mice; antimiR34a 关键词：纳米颗粒；小鼠心肌梗死；心肌修复；antimiR34a 文章编号：2832-9317（2023）02-0041-04 DOI：10.12424/HA.2023.026 本文链接：https://www.oc-press.com/HA-202302-041.html
|
